trialr

A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) doi:10.2307/2531628; EffTox by Thall & Cook (2004) doi:10.1111/j.0006-341X.2004.00218.x; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) doi:10.1002/sim.3230; and the Augmented Binary method by Wason & Seaman (2013) doi:10.1002/sim.5867; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.