CRAN/E | nonmem2rx

nonmem2rx

'nonmem2rx' Converts 'NONMEM' Models to 'rxode2'

Installation

About

'NONMEM' has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 doi:10.1002/psp4.12404). This tool allows you to convert 'NONMEM' models to 'rxode2' (Wang, Hallow and James (2016) doi:10.1002/psp4.12052) and with simple models 'nlmixr2' syntax (Fidler et al (2019) doi:10.1002/psp4.12445). The 'nlmixr2' syntax requires the residual specification to be included and it is not always translated. If available, the 'rxode2' model will read in the 'NONMEM' data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an 'rxode2' model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a 'rxode2' model. This is complementary to the 'babelmixr2' package that translates 'nlmixr2' models to 'NONMEM' and can convert the objects converted from 'nonmem2rx' to a full 'nlmixr2' fit.

nlmixr2.github.io/nonmem2rx/
github.com/nlmixr2/nonmem2rx/

Key Metrics

Version 0.1.3
Published 2023-12-12 137 days ago
Needs compilation? yes
License GPL (≥ 3)
CRAN checks nonmem2rx results
Language en-US

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Maintainer

Maintainer

Matthew Fidler

matthew.fidler@gmail.com

Authors

Matthew Fidler

aut / cre

Philip Delff

ctb

Gabriel Staples

ctb

(string insensitive compare)

Material

README
NEWS
Reference manual
Package source

In Views

Pharmacokinetics

Vignettes

Importing NONMEM into rxode2
Qualify rxode2 model against NONMEM
Simulate Derived Variables from imported NONMEM model
Simulate New dosing with covariates
Simulate New dosing from NONMEM model
Simulate using Parameter Uncertainty

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

nonmem2rx archive

Imports

checkmate
digest
dparser
lotri
Rcpp
rxode2
> 2.0.13
magrittr
cli
tools
utils
data.table
qs
xml2
ggplot2
ggforce
crayon

Suggests

devtools
testthat ≥ 3.0.0
nonmemica
NMdata
nonmem2R
withr
nlme
dplyr
xgxr
vdiffr
knitr
rmarkdown
spelling

LinkingTo

dparser
Rcpp
rxode2parse

Reverse Imports

babelmixr2

Reverse Suggests

ruminate