iTOP

Infers a topology of relationships between different datasets, such as multi-omics and phenotypic data recorded on the same samples. We based this methodology on the RV coefficient (Robert & Escoufier, 1976, doi:10.2307/2347233), a measure of matrix correlation, which we have extended for partial matrix correlations and binary data (Aben et al., 2018, doi:10.1101/293993).