CRAN/E | getmstatistic

getmstatistic

Quantifying Systematic Heterogeneity in Meta-Analysis

Installation

About

Quantifying systematic heterogeneity in meta-analysis using R. The M statistic aggregates heterogeneity information across multiple variants to, identify systematic heterogeneity patterns and their direction of effect in meta-analysis. It's primary use is to identify outlier studies, which either show "null" effects or consistently show stronger or weaker genetic effects than average across, the panel of variants examined in a GWAS meta-analysis. In contrast to conventional heterogeneity metrics (Q-statistic, I-squared and tau-squared) which measure random heterogeneity at individual variants, M measures systematic (non-random) heterogeneity across multiple independently associated variants. Systematic heterogeneity can arise in a meta-analysis due to differences in the study characteristics of participating studies. Some of the differences may include: ancestry, allele frequencies, phenotype definition, age-of-disease onset, family-history, gender, linkage disequilibrium and quality control thresholds. See for statistical statistical theory, documentation and examples.

Citation getmstatistic citation info
magosil86.github.io/getmstatistic/
Bug report File report

Key Metrics

Version 0.2.2
R ≥ 3.1.0
Published 2021-05-09 1055 days ago
Needs compilation? no
License MIT
License File
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Maintainer

Maintainer

Lerato E Magosi

magosil86@gmail.com

Authors

Lerato E Magosi

aut

Jemma C Hopewell

aut

Martin Farrall

aut

Lerato E Magosi

cre

Material

NEWS
Reference manual
Package source

In Views

MetaAnalysis

Vignettes

The M statistic: A simple method to measure the impact of systematic heterogeneity in GWAS meta-analysis.

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

getmstatistic archive

Depends

R ≥ 3.1.0

Imports

ggplot2 ≥ 1.0.1
gridExtra ≥ 0.9.1
gtable ≥ 0.1.2
metafor ≥ 1.9-6
psych ≥ 1.5.1
stargazer ≥ 5.1

Suggests

foreign ≥ 0.8-62
knitr ≥ 1.10.5
testthat
covr
rmarkdown