CRAN/E | gJLS2

gJLS2

A Generalized Joint Location and Scale Framework for Association Testing

Installation

About

An update to the Joint Location-Scale (JLS) testing framework that identifies associated SNPs, gene-sets and pathways with main and/or interaction effects on quantitative traits (Soave et al., 2015; doi:10.1016/j.ajhg.2015.05.015). The JLS method simultaneously tests the null hypothesis of equal mean and equal variance across genotypes, by aggregating association evidence from the individual location/mean-only and scale/variance-only tests using Fisher's method. The generalized joint location-scale (gJLS) framework has been developed to deal specifically with sample correlation and group uncertainty (Soave and Sun, 2017; doi:10.1111/biom.12651). The current release: gJLS2, include additional functionalities that enable analyses of X-chromosome genotype data through novel methods for location (Chen et al., 2021; doi:10.1002/gepi.22422) and scale (Deng et al., 2019; doi:10.1002/gepi.22247).

Key Metrics

Version 0.2.0
R ≥ 3.6.0
Published 2021-09-30 910 days ago
Needs compilation? no
License GPL (≥ 3)
CRAN checks gJLS2 results

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Maintainer

Maintainer

Wei Deng

deng@utstat.toronto.edu

Authors

Wei Deng

aut / cre

Lei Sun

aut

Material

Reference manual
Package source

Vignettes

Introduction

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Depends

R ≥ 3.6.0

Imports

methods
nlme
quantreg
MCMCpack
MASS
plyr
ggplot2
moments

Suggests

knitr
markdown