CRAN/E | coxme

coxme

Mixed Effects Cox Models

Installation

About

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.

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Version 2.2-20
R ≥ 2.10
Published 2024-03-05 24 days ago
Needs compilation? yes
License LGPL-2
CRAN checks coxme results

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Maintainer

Maintainer

Terry M. Therneau

therneau.terry@mayo.edu

Authors

Terry M. Therneau

aut / cre

Material

NEWS
Reference manual
Package source

In Views

Agriculture
MixedModels
Survival

Vignettes

Mixed Effects Cox Models
Coxme and the Laplace Approximation
The lmekin function
Special Variance Structures

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

coxme archive

Depends

survival ≥ 2.36.14
methods
bdsmatrix ≥ 1.3
R ≥ 2.10

Imports

nlme
Matrix ≥ 1.0

Suggests

mvtnorm
kinship2

LinkingTo

bdsmatrix

Reverse Depends

mlma

Reverse Imports

bigQF
famSKATRC
highMLR
jstable
MAGNAMWAR
mlmm.gwas
multisite.accuracy
MXM

Reverse Suggests

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Reverse Enhances

emmeans
MuMIn