combiroc

Provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) doi:10.1038/srep45477 and further described in Bombaci & Rossi (2019) doi:10.1007/978-1-4939-9164-8_16, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. doi:10.1101/2022.01.17.476603.

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