CRAN/E | SubtypeDrug

SubtypeDrug

Prioritization of Candidate Cancer Subtype Specific Drugs

Installation

About

A systematic biology tool was developed to prioritize cancer subtype-specific drugs by integrating genetic perturbation, drug action, biological pathway, and cancer subtype. The capabilities of this tool include inferring patient-specific subpathway activity profiles in the context of gene expression profiles with subtype labels, calculating differentially expressed subpathways based on cultured human cells treated with drugs in the 'cMap' (connectivity map) database, prioritizing cancer subtype specific drugs according to drug-disease reverse association score based on subpathway, and visualization of results (Castelo (2013) doi:10.1186/1471-2105-14-7; Han et al (2019) doi:10.1093/bioinformatics/btz894; Lamb and Justin (2006) doi:10.1126/science.1132939). Please cite using doi:10.1093/bioinformatics/btab011.

Bug report File report

Key Metrics

Version 0.1.5
R ≥ 2.10
Published 2021-05-17 925 days ago
Needs compilation? no
License GPL-2
License GPL-3
CRAN checks SubtypeDrug results

Downloads

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Maintainer

Maintainer

Junwei Han

hanjunwei1981@163.com

Authors

Xudong Han
Junwei Han
Chonghui Liu

Material

Reference manual
Package source

Vignettes

SubtypeDrug: a software package for prioritization of candidate cancer subtype-specific drugs

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

SubtypeDrug archive

Depends

R ≥ 2.10

Imports

BiocGenerics
GSVA
grDevices
graphics
igraph
parallel
pheatmap
rvest
stats
xml2
ChemmineR

Suggests

knitr
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