CRAN/E | SimDissolution

SimDissolution

Modeling and Assessing Similarity of Drug Dissolutions Profiles

Installation

About

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) doi:10.1002/sim.7689 for details.

Key Metrics

Version 0.1.0
Published 2019-09-27 1676 days ago
Needs compilation? no
License GPL-2
License GPL-3
CRAN checks SimDissolution results

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Maintainer

Maintainer

Kathrin Moellenhoff

kathrin.moellenhoff@rub.de

Authors

Kathrin Moellenhoff

Material

Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Depends

dplyr
alabama
mvtnorm
graphics