MultisiteMediation

Multisite causal mediation analysis using the methods proposed by Qin and Hong (2017) doi:10.3102/1076998617694879, Qin, Hong, Deutsch, and Bein (2019) doi:10.1111/rssa.12446, and Qin, Deutsch, and Hong (2021) doi:10.1002/pam.22268. It enables causal mediation analysis in multisite trials, in which individuals are assigned to a treatment or a control group at each site. It allows for estimation and hypothesis testing for not only the population average but also the between-site variance of direct and indirect effects transmitted through one single mediator or two concurrent (conditionally independent) mediators. This strategy conveniently relaxes the assumption of no treatment-by-mediator interaction while greatly simplifying the outcome model specification without invoking strong distributional assumptions. This package also provides a function that can further incorporate a sample weight and a nonresponse weight for multisite causal mediation analysis in the presence of complex sample and survey designs and non-random nonresponse, to enhance both the internal validity and external validity. The package also provides a weighting-based balance checking function for assessing the remaining overt bias.