CRAN/E | DoseFinding

DoseFinding

Planning and Analyzing Dose Finding Experiments

Installation

About

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) doi:10.1002/sim.6052).

Key Metrics

Version 1.1-1
R ≥ 2.15.0
Published 2023-11-02 169 days ago
Needs compilation? yes
License GPL-3
CRAN checks DoseFinding results

Downloads

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Last 30 days 1.071 -13%
Last 90 days 3.588 -3%
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Maintainer

Maintainer

Bjoern Bornkamp

bjoern.bornkamp@novartis.com

Authors

Bjoern Bornkamp

aut / cre

Jose Pinheiro

aut

Frank Bretz

aut

Ludger Sandig

aut

Marius Thomas

aut

Material

ChangeLog
Reference manual
Package source

In Views

ClinicalTrials
ExperimentalDesign

Vignettes

Analysis template MCP-Mod for continuous data
Design and analysis template MCP-Mod for binary data
Frequently Asked Questions for MCP-Mod
Analysis template: MCP-Mod with multiple regimen
Overview DoseFinding package
Sample size template for MCP-Mod for normally distributed data

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

DoseFinding archive

Depends

ggplot2
lattice
mvtnorm
R ≥ 2.15.0

Suggests

numDeriv
Rsolnp
quadprog
parallel
multcomp
knitr
rmarkdown
MASS
testthat
RBesT

Reverse Depends

MCPModGeneral
TestingSimilarity

Reverse Imports

clinDR
clustDRM
dosedesignR
LRcontrast
MCPModBC
uniReg

Reverse Suggests

MCPModPack