BuyseTest

Implementation of the Generalized Pairwise Comparisons (GPC) as defined in Buyse (2010) doi:10.1002/sim.3923 for complete observations, and extended in Peron (2018) doi:10.1177/0962280216658320 to deal with right-censoring. GPC compare two groups of observations (intervention vs. control group) regarding several prioritized endpoints to estimate the probability that a random observation drawn from one group performs better/worse/equivalently than a random observation drawn from the other group. Summary statistics such as the net treatment benefit, win ratio, or win odds are then deduced from these probabilities. Confidence intervals and p-values are obtained based on asymptotic results (Ozenne 2021 doi:10.1177/09622802211037067), non-parametric bootstrap, or permutations. The software enables the use of thresholds of minimal importance difference, stratification, non-prioritized endpoints (O Brien test), and can handle right-censoring and competing-risks.

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