CRAN/E | ActiveDriver

ActiveDriver

Finding Cancer Driver Proteins with Enriched Mutations in Post-Translational Modification Sites

Installation

About

A mutation analysis tool that discovers cancer driver genes with frequent mutations in protein signalling sites such as post-translational modifications (phosphorylation, ubiquitination, etc). The Poisson generalised linear regression model identifies genes where cancer mutations in signalling sites are more frequent than expected from the sequence of the entire gene. Integration of mutations with signalling information helps find new driver genes and propose candidate mechanisms to known drivers. Reference: Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Juri Reimand and Gary D Bader. Molecular Systems Biology (2013) 9:637 doi:10.1038/msb.2012.68.

Key Metrics

Version 1.0.0
R ≥ 3.0
Published 2017-08-23 2221 days ago
Needs compilation? no
License GPL-2
License GPL-3
CRAN checks ActiveDriver results

Downloads

Last 24 hours 0 -100%
Last 7 days 46 -10%
Last 30 days 217 +7%
Last 90 days 644 -23%
Last 365 days 3.258 -41%

Maintainer

Maintainer

Juri Reimand

juri.reimand@utoronto.ca

Authors

Juri Reimand

aut / cre

Material

Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Depends

R ≥ 3.0

Imports

stats
parallel
MASS