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Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, doi:10.1016/j.cct.2014.09.001). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.
github.com/bnaras/ASSISTant | |
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