mtdesign

Implements Mander & Thompson's (2010) doi:10.1016/j.cct.2010.07.008 methods for two-stage designs optimal under the alternative hypothesis for phase II [cancer] trials. Also provides an implementation of Simon's (1989) doi:10.1016/0197-2456(89)90015-9 original methodology and allows exploration of the operating characteristics of sub-optimal designs.