CRAN/E | ToxicR

ToxicR

Analyzing Toxicology Dose-Response Data

Installation

About

Toxicology routines for analyzing dose-response data include dose-response analysis and trend tests. Dose-Response methods are based upon the US EPA's benchmark dose software 3. Methods have been extended to include additional functionality based on World Health Organization guidelines. It further supports the European Food Safety Authority's draft guidance on model averaging. The dose-response methods and datasets used in this package are described in Wheeler et al. (2019) doi:10.1111/risa.13218, Wheeler et al. (2020) doi:10.1111/risa.13537, and Wheeler et al. (2022) doi:10.1002/env.2728. NTP routines are described in Bailer and Portier (1988) doi:10.2307/2531856, Bieler and Williams (1993) doi:10.2307/2532200, Williams (1971) doi:10.2307/2528930, and Shirley (1977) doi:10.2307/2529789.

github.com/NIEHS/ToxicR
Copyright file inst/COPYRIGHTS ToxicR copyright details

Key Metrics

Version 22.8.1.0.2
R ≥ 4.1.0
Published 2022-08-08 599 days ago
Needs compilation? yes
License LGPL (≥ 3)
CRAN checks ToxicR results

Downloads

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Last 365 days 543 -66%

Maintainer

Maintainer

Matt Wheeler

matt.wheeler@nih.gov

Authors

Matt Wheeler

aut / cre

Sooyeong Lim

aut

Eric Wimberly

ctb

Keith Shockley

com

Jennifer Fostel

com

Lonlong Yang

ctb

(Modfied Cochran-Armitage test.)

Dawan Taley

com

Cari Martini

com

Ashwin Raghuraman

ctb

(Modified code for (Jonckheere, Williams etc.) to make them standalone functions.)

Steven Johnson

ctb

(Author of NLOPT.)

Aymeric Stamm

ctb

(Maintainer of nloptr Packag 2.0.1 from which all compile scripts were taken.)

Dirk Eddelbuettel

ctb

(Contributed script to download GSL, as in RcppGSL.)

U.S. Deptartment of Health
Human Services

cph

(Owns Copyright for all ToxicR code outside NLOPT and nloptr scripts.)

Material

README
Reference manual
Package source

Vignettes

ToxicR: Continuous Analysis

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

ToxicR archive

Depends

R ≥ 4.1.0

Imports

Rcpp ≥ 1.0.0
ggplot2 ≥ 3.3.2
shiny ≥ 1.5.0
coda ≥ 0.19-4
scales ≥ 1.1.1
tidyverse ≥ 1.3.0
forcats
ggridges ≥ 0.5.3
doBy ≥ 4.6.11
multcomp ≥ 1.4
dplyr ≥ 1.0.7

Suggests

rmarkdown
actuar ≥ 3.2-0
ggpubr ≥ 0.4.0
testthat ≥3.1.0
gridExtra ≥ 2.3
VIM ≥ 6.1.1
knitr ≥ 1.36
modules
plotly ≥ 4.9.2.1

LinkingTo

Rcpp
RcppEigen
RcppGSL