CRAN/E | DRviaSPCN

DRviaSPCN

Drug Repurposing in Cancer via a Subpathway Crosstalk Network

Installation

About

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Key Metrics

Version 0.1.4
R ≥ 3.6
Published 2024-01-13 95 days ago
Needs compilation? no
License GPL-2
License GPL-3
CRAN checks DRviaSPCN results

Downloads

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Maintainer

Maintainer

Junwei Han

hanjunwei1981@163.com

Authors

Junwei Han

aut / cre / cph

Jiashuo Wu

aut

Material

Reference manual
Package source

Vignettes

DRviaSPCN

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

DRviaSPCN archive

Depends

R ≥ 3.6

Imports

GSVA
clusterProfiler
graphics
igraph
pheatmap
stats
sp
ChemmineR

Suggests

rmarkdown
knitr
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